Research Profile: Multiplexed IMS/TOFMS: the ion mobility marathon

Multiplexed ion mobility spectrometry-orthogonal time-of-flight mass spectrometry.

Ion mobility spectrometry (IMS) coupled to orthogonal time-of-flight mass spectrometry (TOF) has shown significant promise for the characterization of complex biological mixtures. The enormous complexity of biological samples (e.g., from proteomics) and the need for both biological and technical analysis replicates imposes major challenges for multidimensional separation platforms with regard t...

Dynamically multiplexed ion mobility time-of-flight mass spectrometry.

Ion mobility spectrometry-time-of-flight mass spectrometry (IMS-TOFMS) has been increasingly used in analysis of complex biological samples. A major challenge is to transform IMS-TOFMS to a high-sensitivity, high-throughput platform, for example, for proteomics applications. In this work, we have developed and integrated three advanced technologies, including efficient ion accumulation in an io...

Scalable Multiplexed Ion Traps - Phase II

The Scalable Multiplexed Ion Trap II (SMIT II) program based at Georgia Tech Research Institute (GTRI) was funded by IARPA during the period from August 2008 through July 2010. The overall goal was to design, fabricate and test surface ion traps through a closely correlated, multi-disciplinary approach involving design, simulation, fabrication and test facilities at GTRI and the Nanotechnology ...

DETECTION AND MEASUREMENT OF ACETONE IN THE BREATH OF DIABETICS BY ION MOBILITY SPECTROMETRY METHOD

Background: The ion mobility spectrometry (IMS) is an analytical technique that is widely used due to its high sensitivity and speed for the detection of ionized molecules in gas phase and under atmospheric pressure. Breath analysis is a new method for obtaining information about person's clinical conditions that is considered by researchers. Human exhaled air contains a variety of components s...

Ion Mobility-Mass Spectrometry